Protein Details: Neuronal acetylcholine receptor subunit non-alpha-3

Protein ID

ICDB_Pro_0373

Protein Name

Neuronal acetylcholine receptor subunit non-alpha-3

Gene Name

Organism

Carassius auratus (Goldfish)

Length

466 amino acids

AlphaFoldDB

AF-P18257-F1-model_v4.pdb

Function

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane . The channel is permeable to a range of divalent cations including calcium; the influx of which may activate a potassium current which hyperpolarizes the cell membrane . In the ear; this may lead to a reduction in basilar membrane motion; altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion . .

Sequence

MKLQISGLLLVTAVAYATIEAPEEFVSLAEMEDTLLRNLFRGYQKWVRPILHANDTITVRFGLKISQLVDVDEKNHLMTTNVWLWQEWTDYKLRWNPEDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLTLLDAYVDRKDFFDNGEWEILNATGQRGSRRDGIYSYPYVTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLLLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTLFVINVHHRSSATYHPMAPWVKSLFLQRLPRLLCMRGHTDRYQYPDIELRSPELKRGMKKGQQKSAGGGRGGLKEDENQAWIALLEKATHSVHYISRHIKKEHFIREVVQDWKFVAQVLDRIFLWVFLTASVLGTILIFTPALHMYLST

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 146: "Key residue important for potent inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA (AC P0C1D0)"

Disease

Location

Expressed in cochlea; keratinocytes; pituitary gland; B-cells and T-cells

DOI ID

10.1124/mol.61.1.150; 10.1159/000069804; 10.1038/nature03466; 10.1101/gr.2596504; 10.1016/s0002-9440(10)64651-2; 10.1016/j.lfs.2004.05.031; 10.1111/j.1471-4159.2012.07867.x; 10.1038/nsmb.2900

RefSeq

NP_060051.2